Lupus nephritis (LN) is a form of glomerulonephritis that constitutes one of the most severe organ manifestations of systemic lupus erythematosus (SLE).
B cell activating factor BAFF, also known as B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their depletion. Serum BAFF levels are elevated in SLE patients. Excessive BAFF leads to overproduction of antibodies, and a lupus-like phenotype in mice.Knockout mice GemPharmatech has generated the B6-hBAFF mouse model through transgenic overexpression of human BAFF in B6J mice. The B6-hBAFF model exhibits features of autoimmune diseases, including autoantibody production, B cell hyperplasia, and significant lupus nephritis. This model is suitable for autoimmune research, especially lupus nephritis. |
B6-hBAFF mice show significantly increased serum anti-dsDNA antibody levels beginning at 8 weeks of age, which indicates autoimmune reaction and organ damage. |
B6-hBAFF mice show severe renal manifestations at 25 weeks of age.
To advance autoimmune disease research and drug development, GemPharmatech has developed various autoimmune disease models including models of systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and atopic dermatitis (AD).
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